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It is sometimes intended as a pejorative, bearing the implication that the scarce medical research resources allocated to develop such drugs were spent frivolously when they could have been better spent researching cures for more serious medical conditions. The widespread use of antimalarials has been followed by the emergence of drug resistance especially in regions with high drug use. Physically he was weaker than his opponents, who were often much older and taller, and in training he worked on increasing his muscle mass and overall strength in order to be able to shake off defenders. The crenarchaeal virus Sulfolobus turreted icosahedral virus has a similar structure. He was also appointed state chemist of Indiana.
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